The MLL recombinome of acute leukemias in 2017.
Identifieur interne : 000271 ( Main/Exploration ); précédent : 000270; suivant : 000272The MLL recombinome of acute leukemias in 2017.
Auteurs : C. Meyer [Allemagne] ; T. Burmeister [Allemagne] ; D. Gröger [Allemagne] ; G. Tsaur [Russie] ; L. Fechina [Russie] ; A. Renneville [France] ; R. Sutton [Australie] ; N C Venn [Australie] ; M. Emerenciano [Brésil] ; M S Pombo-De-Oliveira [Brésil] ; C. Barbieri Blunck [Brésil] ; B. Almeida Lopes [Brésil] ; J. Zuna [République tchèque] ; J. Trka [République tchèque] ; P. Ballerini [France] ; H. Lapillonne [France] ; M. De Braekeleer [France] ; G. Cazzaniga [Italie] ; L. Corral Abascal [Italie] ; V H J. Van Der Velden [Pays-Bas] ; E. Delabesse [France] ; T S Park [Corée du Sud] ; S H Oh [Corée du Sud] ; M L M. Silva [Brésil] ; T. Lund-Aho [Finlande] ; V. Juvonen [Finlande] ; A S Moore [Australie] ; O. Heidenreich [Royaume-Uni] ; J. Vormoor [Royaume-Uni] ; E. Zerkalenkova [Russie] ; Y. Olshanskaya [Russie] ; C. Bueno [Espagne] ; P. Menendez [Espagne] ; A. Teigler-Schlegel [Allemagne] ; U. Zur Stadt [Allemagne] ; J. Lentes [Allemagne] ; G. Göhring [Allemagne] ; A. Kustanovich ; O. Aleinikova ; B W Sch Fer [Suisse] ; S. Kubetzko [Suisse] ; H O Madsen [Danemark] ; B. Gruhn [Allemagne] ; X. Duarte [Portugal] ; P. Gameiro [Portugal] ; E. Lippert [France] ; A. Bidet [France] ; J M Cayuela [France] ; E. Clappier [France] ; C N Alonso [Argentine] ; C M Zwaan [Pays-Bas] ; M M Van Den Heuvel-Eibrink [Pays-Bas] ; S. Izraeli [Israël] ; L. Trakhtenbrot [Israël] ; P. Archer [Royaume-Uni] ; J. Hancock [Royaume-Uni] ; A. Möricke [Allemagne] ; J. Alten [Allemagne] ; M. Schrappe [Allemagne] ; M. Stanulla [Allemagne] ; S. Strehl [Autriche] ; A. Attarbaschi [Autriche] ; M. Dworzak [Autriche] ; O A Haas [Autriche] ; R. Panzer-Grümayer [Autriche] ; L. Sedék [Pologne] ; T. Szczepa Ski [Pologne] ; A. Caye [France] ; L. Suarez [France] ; H. Cavé [France] ; R. Marschalek [Allemagne]Source :
- Leukemia [ 1476-5551 ] ; 2017.
Abstract
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.Leukemia advance online publication, 8 August 2017; doi:10.1038/leu.2017.213.
DOI: 10.1038/leu.2017.213
PubMed: 28701730
Affiliations:
- Allemagne, Argentine, Australie, Autriche, Brésil, Corée du Sud, Danemark, Espagne, Finlande, France, Israël, Italie, Pays-Bas, Pologne, Portugal, Royaume-Uni, Russie, République tchèque, Suisse
- Berlin, Bohême centrale, Catalogne, District de Darmstadt, District fédéral central, Finlande occidentale, Hambourg, Hauts-de-France, Hesse (Land), Hollande-Méridionale, Hovedstaden, Midi-Pyrénées, Nord-Pas-de-Calais, Occitanie (région administrative), Région Bretagne, Région capitale de Séoul, Schleswig-Holstein, Vienne (Autriche), État de Rio de Janeiro, Île-de-France
- Barcelone, Berlin, Brest, Copenhague, Francfort-sur-le-Main, Hambourg, Kiel, Lille, Moscou, Paris, Prague, Rio de Janeiro, Rotterdam, Séoul, Toulouse, Turku, Vienne (Autriche)
- Université de Bretagne Occidentale
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000956
- to stream PubMed, to step Curation: 000953
- to stream PubMed, to step Checkpoint: 000953
- to stream Ncbi, to step Merge: 004B10
- to stream Ncbi, to step Curation: 004B10
- to stream Ncbi, to step Checkpoint: 004B10
- to stream Main, to step Merge: 000266
- to stream Main, to step Curation: 000271
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The MLL recombinome of acute leukemias in 2017.</title><author><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main</wicri:regionArea><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author><author><name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name><affiliation wicri:level="1"><nlm:affiliation>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg</wicri:regionArea><wicri:noRegion>Ekaterinburg</wicri:noRegion></affiliation></author><author><name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name><affiliation wicri:level="1"><nlm:affiliation>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg</wicri:regionArea><wicri:noRegion>Ekaterinburg</wicri:noRegion></affiliation></author><author><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM, UMR-S 1172, Cancer Research Institute of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM, UMR-S 1172, Cancer Research Institute of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sutton, R" sort="Sutton, R" uniqKey="Sutton R" first="R" last="Sutton">R. Sutton</name><affiliation wicri:level="1"><nlm:affiliation>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Venn, N C" sort="Venn, N C" uniqKey="Venn N" first="N C" last="Venn">N C Venn</name><affiliation wicri:level="1"><nlm:affiliation>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Pombo De Oliveira, M S" sort="Pombo De Oliveira, M S" uniqKey="Pombo De Oliveira M" first="M S" last="Pombo-De-Oliveira">M S Pombo-De-Oliveira</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Barbieri Blunck, C" sort="Barbieri Blunck, C" uniqKey="Barbieri Blunck C" first="C" last="Barbieri Blunck">C. Barbieri Blunck</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Almeida Lopes, B" sort="Almeida Lopes, B" uniqKey="Almeida Lopes B" first="B" last="Almeida Lopes">B. Almeida Lopes</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name><affiliation wicri:level="3"><nlm:affiliation>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name><affiliation wicri:level="3"><nlm:affiliation>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name><affiliation wicri:level="3"><nlm:affiliation>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lapillonne, H" sort="Lapillonne, H" uniqKey="Lapillonne H" first="H" last="Lapillonne">H. Lapillonne</name><affiliation wicri:level="3"><nlm:affiliation>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name><affiliation wicri:level="4"><nlm:affiliation>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique &INSERM-U1078, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique &INSERM-U1078, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Cazzaniga, G" sort="Cazzaniga, G" uniqKey="Cazzaniga G" first="G" last="Cazzaniga">G. Cazzaniga</name><affiliation wicri:level="1"><nlm:affiliation>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Corral Abascal, L" sort="Corral Abascal, L" uniqKey="Corral Abascal L" first="L" last="Corral Abascal">L. Corral Abascal</name><affiliation wicri:level="1"><nlm:affiliation>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus MC, Department of Immunology, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus MC, Department of Immunology, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name><affiliation wicri:level="3"><nlm:affiliation>CHU Purpan, Laboratoire d'Hématologie, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Purpan, Laboratoire d'Hématologie, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Inje University College of Medicine, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name><affiliation wicri:level="3"><nlm:affiliation>Cytogenetics Department, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Cytogenetics Department, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Genetics, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Clinical Genetics, Fimlab Laboratories, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Moore, A S" sort="Moore, A S" uniqKey="Moore A" first="A S" last="Moore">A S Moore</name><affiliation wicri:level="1"><nlm:affiliation>The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name><affiliation wicri:level="1"><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name><affiliation wicri:level="1"><nlm:affiliation>The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Zerkalenkova, E" sort="Zerkalenkova, E" uniqKey="Zerkalenkova E" first="E" last="Zerkalenkova">E. Zerkalenkova</name><affiliation wicri:level="3"><nlm:affiliation>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology, Moscow.</nlm:affiliation><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology</wicri:orgArea></affiliation></author><author><name sortKey="Olshanskaya, Y" sort="Olshanskaya, Y" uniqKey="Olshanskaya Y" first="Y" last="Olshanskaya">Y. Olshanskaya</name><affiliation wicri:level="3"><nlm:affiliation>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology, Moscow.</nlm:affiliation><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology</wicri:orgArea></affiliation></author><author><name sortKey="Bueno, C" sort="Bueno, C" uniqKey="Bueno C" first="C" last="Bueno">C. Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Menendez, P" sort="Menendez, P" uniqKey="Menendez P" first="P" last="Menendez">P. Menendez</name><affiliation wicri:level="3"><nlm:affiliation>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Teigler Schlegel, A" sort="Teigler Schlegel, A" uniqKey="Teigler Schlegel A" first="A" last="Teigler-Schlegel">A. Teigler-Schlegel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Pathology and Cytology, Institute of Pathology, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Pathology and Cytology, Institute of Pathology, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name><affiliation wicri:level="3"><nlm:affiliation>Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Lentes, J" sort="Lentes, J" uniqKey="Lentes J" first="J" last="Lentes">J. Lentes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Hannover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Human Genetics, Hannover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Gohring, G" sort="Gohring, G" uniqKey="Gohring G" first="G" last="Göhring">G. Göhring</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Hannover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Human Genetics, Hannover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name><affiliation><nlm:affiliation>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus.</nlm:affiliation><wicri:noCountry code="subField">Republic of Belarus</wicri:noCountry></affiliation></author><author><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name><affiliation><nlm:affiliation>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus.</nlm:affiliation><wicri:noCountry code="subField">Republic of Belarus</wicri:noCountry></affiliation></author><author><name sortKey="Sch Fer, B W" sort="Sch Fer, B W" uniqKey="Sch Fer B" first="B W" last="Sch Fer">B W Sch Fer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, University Children's Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Kubetzko, S" sort="Kubetzko, S" uniqKey="Kubetzko S" first="S" last="Kubetzko">S. Kubetzko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, University Children's Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Madsen, H O" sort="Madsen, H O" uniqKey="Madsen H" first="H O" last="Madsen">H O Madsen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Immunology, University Hospital Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Immunology, University Hospital Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Gruhn, B" sort="Gruhn, B" uniqKey="Gruhn B" first="B" last="Gruhn">B. Gruhn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Duarte, X" sort="Duarte, X" uniqKey="Duarte X" first="X" last="Duarte">X. Duarte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Pediatrics, Portuguese Institute of Oncology of Lisbon, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Gameiro, P" sort="Gameiro, P" uniqKey="Gameiro P" first="P" last="Gameiro">P. Gameiro</name><affiliation wicri:level="1"><nlm:affiliation>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name><affiliation wicri:level="4"><nlm:affiliation>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Bidet, A" sort="Bidet, A" uniqKey="Bidet A" first="A" last="Bidet">A. Bidet</name><affiliation wicri:level="4"><nlm:affiliation>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alonso, C N" sort="Alonso, C N" uniqKey="Alonso C" first="C N" last="Alonso">C N Alonso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Nacional de Pediatría Prof Dr J. P. Garrahan, Servcio de Hemato-Oncología, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Nacional de Pediatría Prof Dr J. P. Garrahan, Servcio de Hemato-Oncología, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Izraeli, S" sort="Izraeli, S" uniqKey="Izraeli S" first="S" last="Izraeli">S. Izraeli</name><affiliation wicri:level="1"><nlm:affiliation>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Trakhtenbrot, L" sort="Trakhtenbrot, L" uniqKey="Trakhtenbrot L" first="L" last="Trakhtenbrot">L. Trakhtenbrot</name><affiliation wicri:level="1"><nlm:affiliation>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name><affiliation wicri:level="1"><nlm:affiliation>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name><affiliation wicri:level="1"><nlm:affiliation>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Alten, J" sort="Alten, J" uniqKey="Alten J" first="J" last="Alten">J. Alten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, MHH, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, MHH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Strehl, S" sort="Strehl, S" uniqKey="Strehl S" first="S" last="Strehl">S. Strehl</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Attarbaschi, A" sort="Attarbaschi, A" uniqKey="Attarbaschi A" first="A" last="Attarbaschi">A. Attarbaschi</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Dworzak, M" sort="Dworzak, M" uniqKey="Dworzak M" first="M" last="Dworzak">M. Dworzak</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Haas, O A" sort="Haas, O A" uniqKey="Haas O" first="O A" last="Haas">O A Haas</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Panzer Grumayer, R" sort="Panzer Grumayer, R" uniqKey="Panzer Grumayer R" first="R" last="Panzer-Grümayer">R. Panzer-Grümayer</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Sedek, L" sort="Sedek, L" uniqKey="Sedek L" first="L" last="Sedék">L. Sedék</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Medical University of Silesia, Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Microbiology and Immunology, Medical University of Silesia, Zabrze</wicri:regionArea><wicri:noRegion>Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Szczepa Ski, T" sort="Szczepa Ski, T" uniqKey="Szczepa Ski T" first="T" last="Szczepa Ski">T. Szczepa Ski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze</wicri:regionArea><wicri:noRegion>Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Caye, A" sort="Caye, A" uniqKey="Caye A" first="A" last="Caye">A. Caye</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Suarez, L" sort="Suarez, L" uniqKey="Suarez L" first="L" last="Suarez">L. Suarez</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main</wicri:regionArea><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28701730</idno><idno type="pmid">28701730</idno><idno type="doi">10.1038/leu.2017.213</idno><idno type="wicri:Area/PubMed/Corpus">000956</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000956</idno><idno type="wicri:Area/PubMed/Curation">000953</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000953</idno><idno type="wicri:Area/PubMed/Checkpoint">000953</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000953</idno><idno type="wicri:Area/Ncbi/Merge">004B10</idno><idno type="wicri:Area/Ncbi/Curation">004B10</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B10</idno><idno type="wicri:Area/Main/Merge">000266</idno><idno type="wicri:Area/Main/Curation">000271</idno><idno type="wicri:Area/Main/Exploration">000271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The MLL recombinome of acute leukemias in 2017.</title><author><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main</wicri:regionArea><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author><author><name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Department of Hematology, Oncology and Tumorimmunology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name><affiliation wicri:level="1"><nlm:affiliation>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg</wicri:regionArea><wicri:noRegion>Ekaterinburg</wicri:noRegion></affiliation></author><author><name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name><affiliation wicri:level="1"><nlm:affiliation>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Regional Children Hospital 1, Research Institute of Medical Cell Technologies, Pediatric Oncology and Hematology Center, Ural Federal University, Ekaterinburg</wicri:regionArea><wicri:noRegion>Ekaterinburg</wicri:noRegion></affiliation></author><author><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM, UMR-S 1172, Cancer Research Institute of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Hematology, Biology and Pathology Center, CHRU of Lille; INSERM, UMR-S 1172, Cancer Research Institute of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sutton, R" sort="Sutton, R" uniqKey="Sutton R" first="R" last="Sutton">R. Sutton</name><affiliation wicri:level="1"><nlm:affiliation>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Venn, N C" sort="Venn, N C" uniqKey="Venn N" first="N C" last="Venn">N C Venn</name><affiliation wicri:level="1"><nlm:affiliation>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Institute Australia, Uinversity of NSW Sydney, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Pombo De Oliveira, M S" sort="Pombo De Oliveira, M S" uniqKey="Pombo De Oliveira M" first="M S" last="Pombo-De-Oliveira">M S Pombo-De-Oliveira</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Barbieri Blunck, C" sort="Barbieri Blunck, C" uniqKey="Barbieri Blunck C" first="C" last="Barbieri Blunck">C. Barbieri Blunck</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Almeida Lopes, B" sort="Almeida Lopes, B" uniqKey="Almeida Lopes B" first="B" last="Almeida Lopes">B. Almeida Lopes</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Hematology-Oncology Program-Research Center, Instituto Nacional de Cancer Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name><affiliation wicri:level="3"><nlm:affiliation>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name><affiliation wicri:level="3"><nlm:affiliation>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>CLIP, Department of Paediatric Haematology/Oncology, Charles University Prague, 2nd Faculty of Medicine, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name><affiliation wicri:level="3"><nlm:affiliation>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lapillonne, H" sort="Lapillonne, H" uniqKey="Lapillonne H" first="H" last="Lapillonne">H. Lapillonne</name><affiliation wicri:level="3"><nlm:affiliation>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, AP-HP A. Trousseau, Pierre et Marie Curie University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name><affiliation wicri:level="4"><nlm:affiliation>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique &INSERM-U1078, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Laboratoire d'Histologie, Embryologie et Cytogénétique &INSERM-U1078, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Cazzaniga, G" sort="Cazzaniga, G" uniqKey="Cazzaniga G" first="G" last="Cazzaniga">G. Cazzaniga</name><affiliation wicri:level="1"><nlm:affiliation>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Corral Abascal, L" sort="Corral Abascal, L" uniqKey="Corral Abascal L" first="L" last="Corral Abascal">L. Corral Abascal</name><affiliation wicri:level="1"><nlm:affiliation>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Ricerca Tettamanti, Clinica Pediatrica Univ. Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus MC, Department of Immunology, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus MC, Department of Immunology, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name><affiliation wicri:level="3"><nlm:affiliation>CHU Purpan, Laboratoire d'Hématologie, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Purpan, Laboratoire d'Hématologie, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Inje University College of Medicine, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name><affiliation wicri:level="3"><nlm:affiliation>Cytogenetics Department, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Cytogenetics Department, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Genetics, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Clinical Genetics, Fimlab Laboratories, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Moore, A S" sort="Moore, A S" uniqKey="Moore A" first="A S" last="Moore">A S Moore</name><affiliation wicri:level="1"><nlm:affiliation>The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name><affiliation wicri:level="1"><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name><affiliation wicri:level="1"><nlm:affiliation>The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Zerkalenkova, E" sort="Zerkalenkova, E" uniqKey="Zerkalenkova E" first="E" last="Zerkalenkova">E. Zerkalenkova</name><affiliation wicri:level="3"><nlm:affiliation>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology, Moscow.</nlm:affiliation><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology</wicri:orgArea></affiliation></author><author><name sortKey="Olshanskaya, Y" sort="Olshanskaya, Y" uniqKey="Olshanskaya Y" first="Y" last="Olshanskaya">Y. Olshanskaya</name><affiliation wicri:level="3"><nlm:affiliation>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology, Moscow.</nlm:affiliation><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Dmitry Rogachev National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology</wicri:orgArea></affiliation></author><author><name sortKey="Bueno, C" sort="Bueno, C" uniqKey="Bueno C" first="C" last="Bueno">C. Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Menendez, P" sort="Menendez, P" uniqKey="Menendez P" first="P" last="Menendez">P. Menendez</name><affiliation wicri:level="3"><nlm:affiliation>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Teigler Schlegel, A" sort="Teigler Schlegel, A" uniqKey="Teigler Schlegel A" first="A" last="Teigler-Schlegel">A. Teigler-Schlegel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Pathology and Cytology, Institute of Pathology, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Pathology and Cytology, Institute of Pathology, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name><affiliation wicri:level="3"><nlm:affiliation>Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Diagnostic, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Lentes, J" sort="Lentes, J" uniqKey="Lentes J" first="J" last="Lentes">J. Lentes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Hannover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Human Genetics, Hannover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Gohring, G" sort="Gohring, G" uniqKey="Gohring G" first="G" last="Göhring">G. Göhring</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, Hannover Medical School, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Human Genetics, Hannover Medical School, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name><affiliation><nlm:affiliation>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus.</nlm:affiliation><wicri:noCountry code="subField">Republic of Belarus</wicri:noCountry></affiliation></author><author><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name><affiliation><nlm:affiliation>Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus.</nlm:affiliation><wicri:noCountry code="subField">Republic of Belarus</wicri:noCountry></affiliation></author><author><name sortKey="Sch Fer, B W" sort="Sch Fer, B W" uniqKey="Sch Fer B" first="B W" last="Sch Fer">B W Sch Fer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, University Children's Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Kubetzko, S" sort="Kubetzko, S" uniqKey="Kubetzko S" first="S" last="Kubetzko">S. Kubetzko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology, University Children's Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Madsen, H O" sort="Madsen, H O" uniqKey="Madsen H" first="H O" last="Madsen">H O Madsen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Immunology, University Hospital Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Immunology, University Hospital Rigshospitalet, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Gruhn, B" sort="Gruhn, B" uniqKey="Gruhn B" first="B" last="Gruhn">B. Gruhn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Duarte, X" sort="Duarte, X" uniqKey="Duarte X" first="X" last="Duarte">X. Duarte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Pediatrics, Portuguese Institute of Oncology of Lisbon, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Gameiro, P" sort="Gameiro, P" uniqKey="Gameiro P" first="P" last="Gameiro">P. Gameiro</name><affiliation wicri:level="1"><nlm:affiliation>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Hemato-Oncology Laboratory, UIPM, Portuguese Institute of Oncology of Lisbon, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name><affiliation wicri:level="4"><nlm:affiliation>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Bidet, A" sort="Bidet, A" uniqKey="Bidet A" first="A" last="Bidet">A. Bidet</name><affiliation wicri:level="4"><nlm:affiliation>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hématologie Biologique, CHU de Brest and INSERM U1078, Université de Bretagne Occidentale, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement><settlement type="city">Brest</settlement></placeName><orgName type="university">Université de Bretagne Occidentale</orgName></affiliation></author><author><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'hématologie, AP-HP Saint-Louis, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alonso, C N" sort="Alonso, C N" uniqKey="Alonso C" first="C N" last="Alonso">C N Alonso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Nacional de Pediatría Prof Dr J. P. Garrahan, Servcio de Hemato-Oncología, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Nacional de Pediatría Prof Dr J. P. Garrahan, Servcio de Hemato-Oncología, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Izraeli, S" sort="Izraeli, S" uniqKey="Izraeli S" first="S" last="Izraeli">S. Izraeli</name><affiliation wicri:level="1"><nlm:affiliation>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Trakhtenbrot, L" sort="Trakhtenbrot, L" uniqKey="Trakhtenbrot L" first="L" last="Trakhtenbrot">L. Trakhtenbrot</name><affiliation wicri:level="1"><nlm:affiliation>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Chaim Sheba Medical Center, Department of Pediatric Hemato-Oncology and the Cancer Research Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name><affiliation wicri:level="1"><nlm:affiliation>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name><affiliation wicri:level="1"><nlm:affiliation>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol Genetics Laboratory, Pathology Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Alten, J" sort="Alten, J" uniqKey="Alten J" first="J" last="Alten">J. Alten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, MHH, Hanover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, MHH, Hanover</wicri:regionArea><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion><wicri:noRegion>Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Strehl, S" sort="Strehl, S" uniqKey="Strehl S" first="S" last="Strehl">S. Strehl</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Attarbaschi, A" sort="Attarbaschi, A" uniqKey="Attarbaschi A" first="A" last="Attarbaschi">A. Attarbaschi</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Dworzak, M" sort="Dworzak, M" uniqKey="Dworzak M" first="M" last="Dworzak">M. Dworzak</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Haas, O A" sort="Haas, O A" uniqKey="Haas O" first="O A" last="Haas">O A Haas</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Panzer Grumayer, R" sort="Panzer Grumayer, R" uniqKey="Panzer Grumayer R" first="R" last="Panzer-Grümayer">R. Panzer-Grümayer</name><affiliation wicri:level="3"><nlm:affiliation>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute and St Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Sedek, L" sort="Sedek, L" uniqKey="Sedek L" first="L" last="Sedék">L. Sedék</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Medical University of Silesia, Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Microbiology and Immunology, Medical University of Silesia, Zabrze</wicri:regionArea><wicri:noRegion>Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Szczepa Ski, T" sort="Szczepa Ski, T" uniqKey="Szczepa Ski T" first="T" last="Szczepa Ski">T. Szczepa Ski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze</wicri:regionArea><wicri:noRegion>Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Caye, A" sort="Caye, A" uniqKey="Caye A" first="A" last="Caye">A. Caye</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Suarez, L" sort="Suarez, L" uniqKey="Suarez L" first="L" last="Suarez">L. Suarez</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, AP-HP Robert Debré, Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University, Frankfurt/Main</wicri:regionArea><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="eISSN">1476-5551</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.Leukemia advance online publication, 8 August 2017; doi:10.1038/leu.2017.213.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Autriche</li><li>Brésil</li><li>Corée du Sud</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Portugal</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suisse</li></country><region><li>Berlin</li><li>Bohême centrale</li><li>Catalogne</li><li>District de Darmstadt</li><li>District fédéral central</li><li>Finlande occidentale</li><li>Hambourg</li><li>Hauts-de-France</li><li>Hesse (Land)</li><li>Hollande-Méridionale</li><li>Hovedstaden</li><li>Midi-Pyrénées</li><li>Nord-Pas-de-Calais</li><li>Occitanie (région administrative)</li><li>Région Bretagne</li><li>Région capitale de Séoul</li><li>Schleswig-Holstein</li><li>Vienne (Autriche)</li><li>État de Rio de Janeiro</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Berlin</li><li>Brest</li><li>Copenhague</li><li>Francfort-sur-le-Main</li><li>Hambourg</li><li>Kiel</li><li>Lille</li><li>Moscou</li><li>Paris</li><li>Prague</li><li>Rio de Janeiro</li><li>Rotterdam</li><li>Séoul</li><li>Toulouse</li><li>Turku</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de Bretagne Occidentale</li></orgName></list><tree><noCountry><name sortKey="Aleinikova, O" sort="Aleinikova, O" uniqKey="Aleinikova O" first="O" last="Aleinikova">O. Aleinikova</name><name sortKey="Kustanovich, A" sort="Kustanovich, A" uniqKey="Kustanovich A" first="A" last="Kustanovich">A. Kustanovich</name></noCountry><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Meyer, C" sort="Meyer, C" uniqKey="Meyer C" first="C" last="Meyer">C. Meyer</name></region><name sortKey="Alten, J" sort="Alten, J" uniqKey="Alten J" first="J" last="Alten">J. Alten</name><name sortKey="Burmeister, T" sort="Burmeister, T" uniqKey="Burmeister T" first="T" last="Burmeister">T. Burmeister</name><name sortKey="Gohring, G" sort="Gohring, G" uniqKey="Gohring G" first="G" last="Göhring">G. Göhring</name><name sortKey="Groger, D" sort="Groger, D" uniqKey="Groger D" first="D" last="Gröger">D. Gröger</name><name sortKey="Gruhn, B" sort="Gruhn, B" uniqKey="Gruhn B" first="B" last="Gruhn">B. Gruhn</name><name sortKey="Lentes, J" sort="Lentes, J" uniqKey="Lentes J" first="J" last="Lentes">J. Lentes</name><name sortKey="Marschalek, R" sort="Marschalek, R" uniqKey="Marschalek R" first="R" last="Marschalek">R. Marschalek</name><name sortKey="Moricke, A" sort="Moricke, A" uniqKey="Moricke A" first="A" last="Möricke">A. Möricke</name><name sortKey="Schrappe, M" sort="Schrappe, M" uniqKey="Schrappe M" first="M" last="Schrappe">M. Schrappe</name><name sortKey="Stanulla, M" sort="Stanulla, M" uniqKey="Stanulla M" first="M" last="Stanulla">M. Stanulla</name><name sortKey="Teigler Schlegel, A" sort="Teigler Schlegel, A" uniqKey="Teigler Schlegel A" first="A" last="Teigler-Schlegel">A. Teigler-Schlegel</name><name sortKey="Zur Stadt, U" sort="Zur Stadt, U" uniqKey="Zur Stadt U" first="U" last="Zur Stadt">U. Zur Stadt</name></country><country name="Russie"><noRegion><name sortKey="Tsaur, G" sort="Tsaur, G" uniqKey="Tsaur G" first="G" last="Tsaur">G. Tsaur</name></noRegion><name sortKey="Fechina, L" sort="Fechina, L" uniqKey="Fechina L" first="L" last="Fechina">L. Fechina</name><name sortKey="Olshanskaya, Y" sort="Olshanskaya, Y" uniqKey="Olshanskaya Y" first="Y" last="Olshanskaya">Y. Olshanskaya</name><name sortKey="Zerkalenkova, E" sort="Zerkalenkova, E" uniqKey="Zerkalenkova E" first="E" last="Zerkalenkova">E. Zerkalenkova</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Renneville, A" sort="Renneville, A" uniqKey="Renneville A" first="A" last="Renneville">A. Renneville</name></region><name sortKey="Ballerini, P" sort="Ballerini, P" uniqKey="Ballerini P" first="P" last="Ballerini">P. Ballerini</name><name sortKey="Bidet, A" sort="Bidet, A" uniqKey="Bidet A" first="A" last="Bidet">A. Bidet</name><name sortKey="Cave, H" sort="Cave, H" uniqKey="Cave H" first="H" last="Cavé">H. Cavé</name><name sortKey="Caye, A" sort="Caye, A" uniqKey="Caye A" first="A" last="Caye">A. Caye</name><name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J M" last="Cayuela">J M Cayuela</name><name sortKey="Clappier, E" sort="Clappier, E" uniqKey="Clappier E" first="E" last="Clappier">E. Clappier</name><name sortKey="De Braekeleer, M" sort="De Braekeleer, M" uniqKey="De Braekeleer M" first="M" last="De Braekeleer">M. De Braekeleer</name><name sortKey="Delabesse, E" sort="Delabesse, E" uniqKey="Delabesse E" first="E" last="Delabesse">E. Delabesse</name><name sortKey="Lapillonne, H" sort="Lapillonne, H" uniqKey="Lapillonne H" first="H" last="Lapillonne">H. Lapillonne</name><name sortKey="Lippert, E" sort="Lippert, E" uniqKey="Lippert E" first="E" last="Lippert">E. Lippert</name><name sortKey="Suarez, L" sort="Suarez, L" uniqKey="Suarez L" first="L" last="Suarez">L. Suarez</name></country><country name="Australie"><noRegion><name sortKey="Sutton, R" sort="Sutton, R" uniqKey="Sutton R" first="R" last="Sutton">R. Sutton</name></noRegion><name sortKey="Moore, A S" sort="Moore, A S" uniqKey="Moore A" first="A S" last="Moore">A S Moore</name><name sortKey="Venn, N C" sort="Venn, N C" uniqKey="Venn N" first="N C" last="Venn">N C Venn</name></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Emerenciano, M" sort="Emerenciano, M" uniqKey="Emerenciano M" first="M" last="Emerenciano">M. Emerenciano</name></region><name sortKey="Almeida Lopes, B" sort="Almeida Lopes, B" uniqKey="Almeida Lopes B" first="B" last="Almeida Lopes">B. Almeida Lopes</name><name sortKey="Barbieri Blunck, C" sort="Barbieri Blunck, C" uniqKey="Barbieri Blunck C" first="C" last="Barbieri Blunck">C. Barbieri Blunck</name><name sortKey="Pombo De Oliveira, M S" sort="Pombo De Oliveira, M S" uniqKey="Pombo De Oliveira M" first="M S" last="Pombo-De-Oliveira">M S Pombo-De-Oliveira</name><name sortKey="Silva, M L M" sort="Silva, M L M" uniqKey="Silva M" first="M L M" last="Silva">M L M. Silva</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Zuna, J" sort="Zuna, J" uniqKey="Zuna J" first="J" last="Zuna">J. Zuna</name></region><name sortKey="Trka, J" sort="Trka, J" uniqKey="Trka J" first="J" last="Trka">J. Trka</name></country><country name="Italie"><noRegion><name sortKey="Cazzaniga, G" sort="Cazzaniga, G" uniqKey="Cazzaniga G" first="G" last="Cazzaniga">G. Cazzaniga</name></noRegion><name sortKey="Corral Abascal, L" sort="Corral Abascal, L" uniqKey="Corral Abascal L" first="L" last="Corral Abascal">L. Corral Abascal</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name></region><name sortKey="Van Den Heuvel Eibrink, M M" sort="Van Den Heuvel Eibrink, M M" uniqKey="Van Den Heuvel Eibrink M" first="M M" last="Van Den Heuvel-Eibrink">M M Van Den Heuvel-Eibrink</name><name sortKey="Zwaan, C M" sort="Zwaan, C M" uniqKey="Zwaan C" first="C M" last="Zwaan">C M Zwaan</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, T S" sort="Park, T S" uniqKey="Park T" first="T S" last="Park">T S Park</name></region><name sortKey="Oh, S H" sort="Oh, S H" uniqKey="Oh S" first="S H" last="Oh">S H Oh</name></country><country name="Finlande"><noRegion><name sortKey="Lund Aho, T" sort="Lund Aho, T" uniqKey="Lund Aho T" first="T" last="Lund-Aho">T. Lund-Aho</name></noRegion><name sortKey="Juvonen, V" sort="Juvonen, V" uniqKey="Juvonen V" first="V" last="Juvonen">V. Juvonen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Heidenreich, O" sort="Heidenreich, O" uniqKey="Heidenreich O" first="O" last="Heidenreich">O. Heidenreich</name></noRegion><name sortKey="Archer, P" sort="Archer, P" uniqKey="Archer P" first="P" last="Archer">P. Archer</name><name sortKey="Hancock, J" sort="Hancock, J" uniqKey="Hancock J" first="J" last="Hancock">J. Hancock</name><name sortKey="Vormoor, J" sort="Vormoor, J" uniqKey="Vormoor J" first="J" last="Vormoor">J. Vormoor</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Bueno, C" sort="Bueno, C" uniqKey="Bueno C" first="C" last="Bueno">C. Bueno</name></region><name sortKey="Menendez, P" sort="Menendez, P" uniqKey="Menendez P" first="P" last="Menendez">P. Menendez</name></country><country name="Suisse"><noRegion><name sortKey="Sch Fer, B W" sort="Sch Fer, B W" uniqKey="Sch Fer B" first="B W" last="Sch Fer">B W Sch Fer</name></noRegion><name sortKey="Kubetzko, S" sort="Kubetzko, S" uniqKey="Kubetzko S" first="S" last="Kubetzko">S. Kubetzko</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Madsen, H O" sort="Madsen, H O" uniqKey="Madsen H" first="H O" last="Madsen">H O Madsen</name></region></country><country name="Portugal"><noRegion><name sortKey="Duarte, X" sort="Duarte, X" uniqKey="Duarte X" first="X" last="Duarte">X. Duarte</name></noRegion><name sortKey="Gameiro, P" sort="Gameiro, P" uniqKey="Gameiro P" first="P" last="Gameiro">P. Gameiro</name></country><country name="Argentine"><noRegion><name sortKey="Alonso, C N" sort="Alonso, C N" uniqKey="Alonso C" first="C N" last="Alonso">C N Alonso</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Izraeli, S" sort="Izraeli, S" uniqKey="Izraeli S" first="S" last="Izraeli">S. Izraeli</name></noRegion><name sortKey="Trakhtenbrot, L" sort="Trakhtenbrot, L" uniqKey="Trakhtenbrot L" first="L" last="Trakhtenbrot">L. Trakhtenbrot</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Strehl, S" sort="Strehl, S" uniqKey="Strehl S" first="S" last="Strehl">S. Strehl</name></region><name sortKey="Attarbaschi, A" sort="Attarbaschi, A" uniqKey="Attarbaschi A" first="A" last="Attarbaschi">A. Attarbaschi</name><name sortKey="Dworzak, M" sort="Dworzak, M" uniqKey="Dworzak M" first="M" last="Dworzak">M. Dworzak</name><name sortKey="Haas, O A" sort="Haas, O A" uniqKey="Haas O" first="O A" last="Haas">O A Haas</name><name sortKey="Panzer Grumayer, R" sort="Panzer Grumayer, R" uniqKey="Panzer Grumayer R" first="R" last="Panzer-Grümayer">R. Panzer-Grümayer</name></country><country name="Pologne"><noRegion><name sortKey="Sedek, L" sort="Sedek, L" uniqKey="Sedek L" first="L" last="Sedék">L. Sedék</name></noRegion><name sortKey="Szczepa Ski, T" sort="Szczepa Ski, T" uniqKey="Szczepa Ski T" first="T" last="Szczepa Ski">T. Szczepa Ski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000271 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000271 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28701730
|texte= The MLL recombinome of acute leukemias in 2017.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28701730" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |